Ka la 12 Mots'eanong, 2025, CARsgen e phatlalatsa lintlha tsa pele tsa bongaka bakeng sa CT0596, e leng CAR-T e shebaneng le allogeneic BCMA e entsoeng ho sebelisoa sethala sa THANK-u Plus™. CT0596 hajoale e ntse e hlahlojoa thutong ea pele ea bongaka e hlahlobang myeloma e ngata e khutlisetsoang morao/e sa hlaseleng (R/R MM) kapa leukemia ea sele ea plasma e khutlisetsoang morao/e sa hlaseleng morao (R/R PCL) ho lekola polokeho ea eona, le katleho ea eona ea pele.
Ho tloha ka la 6 Mots'eanong, 2025, bakuli ba 8 ba nang le R/R MM ba neng ba fumane bonyane mela e meraro ea pele ea phekolo ba ile ba ngolisoa 'me ba tšeloa CT0596 kamora ho noa lymphocyte ka regimen ea FC (fludarabine 22.5-30 mg/m² le cyclophosphamide 350-500 mg/m²). Liphihlelo tsa bohlokoa ho tloha likhoeling tse fihlang ho tse 'ne tsa tlhahlobo li kenyelletsa:
Ha ho na lintho tse kotsi tse fokotsang tekanyo (DLTs), ≥Kereiti ya 3 cytokine release syndrome (CRS), immune effector cell-associated neurotoxicity syndrome (ICANS), kapa graft-versus-host disease (GVHD) tse tlalehilweng. Sehlahisoa sena se bontshitse boemo bo botle ba polokeho, ha ho bakuli ba ileng ba emisa kalafo ka lebaka la diketsahalo tse mpe.
1) Har'a bakuli ba 5 ba qetileng tlhahlobo ea pele ea katleho Bekeng ea 4, bakuli ba 3 (60%) ba fihletse karabelo e tiileng/karabelo e felletseng (sCR/CR), 'me bakuli ba 4 (80%) ba fihletse lefu le saletseng hanyane (MRD) - negativity mokong oa masapo. 2) Lintlha tsa pele tsa katleho ho tsoa ho bakuli ba 2 ka Letsatsi la 14 li bontšitse phokotso ea liso tse ka lekanngoang ka ≥92% le ≥65%, ka ho latellana. 3) Mokuli a le mong o ne a e-so fihlelle nako ea tlhahlobo ea katleho e boletsoeng ke protocol.
Bakuli bohle ba sCR/CR ba ile ba sala ba ntse ba arabela ka tsela e tsoelang pele, ho kenyeletsoa le mokuli oa pele ea qetileng tlhahlobo ea likhoeli tse 'ne.
Ho latela lintlha tsa pele tsa polokeho le katleho, CT0596 e bontšitse mamello e ntle le ho khothaletsa matšoao a katleho ho bakuli ba R/R MM ho pholletsa le maemo ohle a tekanyetso a boletsoeng esale pele, ka katoloso ea CAR-T e bonoe. Liphihlelo tsena li hloka hore ho etsoe lipatlisiso tse ling eseng feela ho R/R MM, empa hape le ho mafu a mang a kankere ea lisele tsa plasma le mafu a autoimmune a tsamaisoang ke lisele tsa plasma tse sebetsang ka botsona.
Hona jwale, ho ntse ho na le diteko tse ngata tsa bongaka tsa mahlale a matjha a ho lwantsha kankere Chaena a batlang bakudi. Dipuisano mabapi le meriana le mahlale a matjha, o ka ikopanya le Lefapha la Matjhaba la Sepetlele sa Oncology sa Beijing Region South.
Nomoro ea mohala: 4008803716
Email：myimmnet@163.com
Nako ea poso: Mots'eanong-15-2025